Search results
Results from the WOW.Com Content Network
Laboratory findings include low-normal serum calcium, moderately low serum phosphate, elevated serum alkaline phosphatase, and low serum 1,25 dihydroxy-vitamin D levels, hyperphosphaturia, and no evidence of hyperparathyroidism. [8] Hypophosphatemia decreases 2,3-bisphosphoglycerate (2,3-BPG) causing a left shift in the oxyhemoglobin curve.
Hypophosphatasia (/ ˌ h aɪ p oʊ ˈ f ɒ s f eɪ t ˌ eɪ ʒ ə /; also called deficiency of alkaline phosphatase, phosphoethanolaminuria, [5] or Rathbun's syndrome; [1] sometimes abbreviated HPP [6]) is a rare, and sometimes fatal, inherited [7] metabolic bone disease. [8]
Hypophosphatasia is caused by a genetic defect of tissue-nonspecific alkaline phosphatase (TNSALP), an enzyme that plays a role in bone mineralization. Asfotase alfa is a recombinant glycoprotein that contains the catalytic domain (the active site) of TNSALP. It is thus a form of enzyme replacement therapy. [5] [12]
The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase, also abbreviated PhoA) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function, but in different structural forms suitable to the environment they function in. Alkaline phosphatase is found ...
The Mayo Building is the main center of the Mayo Clinic in Rochester, Minnesota. When the original 10-story Mayo Building was completed in 1955 by designers of Ellerbe & Co., it had been the largest construction project undertaken by Mayo. The Mayo Clinic features artwork by many famous artists such as Andy Warhol. [2]
Surgery as a treatment was first carried out in 1925. [32] The United States prevalence of primary hyperparathyroidism from 2010 was 233 per 100,000 women and 85 per 100,000 men. Black and white women aged 70–79 have the highest overall prevalence. [ 62 ]
Dec. 4—EAU CLAIRE — Mayo Clinic Health System opened a new Spine Center which will help people with back pain receive the correct treatment quickly. On Monday, Mayo Clinic opened the new center.
The hospital ultimately merged with the Skemp Clinic, which was itself formed in 1923 by Dr. Archibald Skemp. The joint venture came to be known as Franciscan Skemp Medical Center. In 1995, Franciscan Skemp Healthcare merged with Mayo Clinic out of Rochester, Minnesota and became known as Mayo Clinic Health System Franciscan -- Franciscan ...