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One can see red blood cells, several knobby white blood cells including lymphocytes, a monocyte, a neutrophil, and many small disc-shaped platelets. A monocyte count is part of a complete blood count and is expressed either as a percentage of monocytes among all white blood cells or as absolute numbers. Both may be useful, but these cells ...
Carbon debris from lungs; General macrophage targets [8] Dendritic cell: Monocyte: Dendritic cell: DC; Cellula dendritiformis; 10-15 Process antigen material and ...
Macrophages are diffusely scattered in the connective tissue and in liver (Kupffer cells), spleen and lymph nodes (sinus histiocytes), lungs (alveolar macrophages), and central nervous system (microglia). The half-life of blood monocytes is about 1 day, whereas the life span of tissue macrophages is several months or years.
Although up to 2% of the cells die most migrate from the blood to the tissues, mainly the intestines and lungs, where pathogens are most likely to be encountered. [104] Some monocytes leave the blood circulation and migrate to the muscles where they differentiate and become macrophages. [104]
T H 1 cells also help recruit more monocytes, the precursor to macrophages, to the infection site. T H 1 secretion TNF-α and LT-α to make blood vessels easier for monocytes to bind to and exit. [34] T H 1 secretion of CCL2 as a chemoattractant for monocytes. IL-3 and GM-CSF released by T H 1 cells stimulate more monocyte production in the ...
Monocytosis is an increase in the number of monocytes circulating in the blood. [1] Monocytes are white blood cells that give rise to macrophages and dendritic cells in the immune system. In humans, monocytosis occurs when there is a sustained rise in monocyte counts greater than 800/mm 3 to 1000/mm 3. [2]
Monocytes form two groups: a circulating group and a marginal group that remain in other tissues (approximately 70% are in the marginal group). Most monocytes leave the blood stream after 20–40 hours to travel to tissues and organs and in doing so transform into macrophages [ 70 ] or dendritic cells depending on the signals they receive. [ 71 ]
The adult human body is estimated to contain about 30 trillion (3×10 13) human cells, with the number varying between 20 and 100 trillion depending on factors such as sex, age, and weight.