Ad
related to: raf kinases in cancer research- Ways to Give Back
Donate, fundraise, shop, or match.
Make a charitable bequest, registry
- Donate Now
Make a donation to lifesaving
cancer immunotherapy research.
- Make A Sustained Impact
Donate a small amount every month
to support ongoing cancer research.
- Why Donate?
We can change the way cancer is
treated and cured. Make an impact.
- Ways to Give Back
Search results
Results from the WOW.Com Content Network
RAF is an acronym for Rapidly Accelerated Fibrosarcoma. [12] RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. [11] Activation of RAF kinases requires interaction with RAS-GTPases. The three RAF kinase family members are: A-RAF; B-RAF; c-Raf
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme [4] that in humans is encoded by the RAF1 gene. [ 5 ] [ 6 ] The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. [ 7 ]
Activated Ras then activates the protein kinase activity of a RAF kinase. [4] The RAF kinase phosphorylates and activates a MAPK/ERK Kinase (MEK1 or MEK2). The MEK phosphorylates and activates a mitogen-activated protein kinase (MAPK). RAF and MAPK/ERK are both serine/threonine-specific protein kinases. MEK is a serine/tyrosine/threonine kinase.
Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene. [5] A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases. [6] Compared to the other members of this family (Raf-1 and B-Raf), very little is known about A-Raf.
B-Raf is a 766-amino acid, regulated signal transduction serine/threonine-specific protein kinase.Broadly speaking, it is composed of three conserved domains characteristic of the Raf kinase family: conserved region 1 (CR1), a Ras-GTP-binding [11] self-regulatory domain, conserved region 2 (CR2), a serine-rich hinge region, and conserved region 3 (CR3), a catalytic protein kinase domain that ...
Cytoplasmic Serine/threonine kinases and their regulatory subunits: Raf kinase, and cyclin-dependent kinases (through overexpression). malignant melanoma, papillary thyroid cancer, colorectal cancer, and ovarian cancer [31] involved in organism development, cell cycle regulation, cell proliferation, differentiation, cells survival, and ...
The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell. [1] RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1- MEK 1/2, ERK 1/2 and NF-kappaB signalling pathways, by interaction with the Raf-1 kinase.
RAF activates MEK. Activated MEK phoshorylates ERK which can now be transported across the cell membrane by a transporter. Dephosphorylated ERK cannot leave the nucleus. MAPK phosphatases (MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling.
Ad
related to: raf kinases in cancer research