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0.9 kilograms (2.0 lb) per month more than placebo [75] Amphetamine salts: Obetrol: Approved 1960, withdrawn 1973; Adderall was later approved for ADHD and narcolepsy and is still used for those purposes Phenylpropanolamine: Was an over-the-counter medication ingredient Withdrawn in 2005 due to risk of hemorragic stroke: 1.5 kilograms (3.3 lb) [76]
Like other sympathomimetic appetite suppressants, mazindol is thought to act as a reuptake inhibitor of norepinephrine, dopamine, and serotonin. The recommended dosage is 2 mg per day for 90 days in patients 40 kg overweight and under; 4 mg a day in patients more than 50 kg overweight; divided into two doses separated by a 12-hour window ...
Drinking water prior to each meal may help in appetite suppression. Consumption of 500 mL (18 imp fl oz; 17 US fl oz) of water 30 minutes before meals has been correlated with modest weight loss (1–2 kg; 2.2–4.4 lb) in obese men and women over a period of 8 to 12 weeks. [9] [10]
Originally it had been reported that Tesofensine has IC 50 of 8.0, 3.2 and 11.0nM at the DAT, NAT (NET) and 5HTT. [12] More recently, though, the following data was submitted: IC 50 (nM) NE 1.7, SER 11, DA 6.5.[ [ 13 ] cited in [ 14 ] ] The revised IC 50 's would adequately explain the lack of efficacy in treating Parkinson's disease , i.e ...
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Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant effects. [8] [9] [10] Chemically, it is a substituted amphetamine. [11] Phentermine was approved for medical use in the United States in 1959. [3] It is available as a generic medication. [3]
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