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The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. [5] Calcitriol (the active form of vitamin D , 1,25-(OH) 2 vitamin D 3 ) binds to VDR, which then forms a heterodimer with the retinoid-X receptor .
The VDR is widely distributed in tissues, and is not restricted to those tissues considered the classic targets of vitamin D. The VDR upon binding to 1,25(OH) 2 D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This VDR/RXR heterodimer complex binds to the specific VDRE in the promoters of ...
The rostral ventrolateral medulla (RVLM), also known as the pressor area of the medulla, is a part of the ventrolateral medulla in the brainstem responsible for basal and reflex control of sympathetic activity associated with cardiovascular function. [1]
Embryonic vertebrate subdivisions of the developing human brain hindbrain or rhombencephalon is a developmental categorization of portions of the central nervous system in vertebrates. It includes the medulla , pons , and cerebellum .
The rostral ventromedial medulla (RVM), or ventromedial nucleus of the spinal cord, [1] [2] is a group of neurons located close to the midline on the floor of the medulla oblongata. The rostral ventromedial medulla sends descending inhibitory and excitatory fibers to the dorsal horn spinal cord neurons . [ 3 ]
In a situation of lowered blood volume, secretion of renin by the kidneys results in the production of angiotensin II, which stimulates receptors in the VOLT and subfornical organ to complete a positive feedback loop. [9] [12] [13] These neurons also project to the median preoptic nucleus which is involved in controlling thirst. [11] [9] [12]
High-voltage-gated calcium channels include the neural N-type channel blocked by ω-conotoxin GVIA, the R-type channel (R stands for Resistant to the other blockers and toxins, except SNX-482) involved in poorly defined processes in the brain, the closely related P/Q-type channel blocked by ω-agatoxins, and the dihydropyridine-sensitive L-type ...
This is because the medulla oblongata is located in the area of the brain, the most inferior portion, which does not have a robust and highly developed blood-brain barrier. Without this barrier, emetic drugs and toxins are free to interact with a receptor , or multiple receptors located in the CTZ.