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A blood substitute (also called artificial blood or blood surrogate) is a substance used to mimic and fulfill some functions of biological blood. It aims to provide an alternative to blood transfusion , which is transferring blood or blood-based products from one person into another.
It is a 13kbp gene on chromosome 21q22.3 that encodes 545 amino acids. [6] AIRE is a transcription factor expressed in the medulla [broken anchor] (inner part) of the thymus. It is part of the mechanism which eliminates self-reactive T cells that would cause autoimmune disease. It exposes T cells to normal, healthy proteins from all parts of ...
Uniporter carrier proteins work by binding to one molecule or substrate at a time. Uniporter channels open in response to a stimulus and allow the free flow of specific molecules. [2] There are several ways in which the opening of uniporter channels may be regulated: Voltage – Regulated by the difference in voltage across the membrane
[5] [6] [7] When a channel is opened, millions of ions can pass through the membrane per second, but only 100 to 1000 molecules typically pass through a carrier molecule in the same time. [8] Each carrier protein is designed to recognize only one substance or one group of very similar substances.
In 2001 Pfizer/Wyeth's drug Gemtuzumab ozogamicin (trade name: Mylotarg) was approved based on a study with a surrogate endpoint, through the accelerated approval process. In June 2010, after evidence accumulated showing no evidence of benefit and significant toxicity, the U.S. Food and Drug Administration (FDA) forced the company to withdraw ...
[citation needed] Jet fuel is an example of a fuel requiring a surrogate for experimental research and numerical modelling due to its complexity and high content variability from one batch to the next. [1] [non-primary source needed] Neat hydrocarbon jet fuel surrogate components include decane, dodecane, methylcyclohexane, and toluene.
A hydrogen carrier is an organic macromolecule that transports atoms of hydrogen from one place to another inside a cell or from cell to cell for use in various metabolical processes. [1] Examples include NADPH , NADH , and FADH .
The simplest aryl group is phenyl, which is made up of a benzene ring with one of its hydrogen atom replaced by some substituent, and has the molecular formula C 6 H 5 −. Note that a phenyl group is not the same as a benzyl group, the latter consisting of a phenyl group attached to a methyl group and a molecular formula of C 6 H 5 CH 2 −. [2]