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Buspirone has also been found to bind with much higher affinity to the dopamine D 3 and D 4 receptors, where it is similarly an antagonist. [45] A major metabolite of buspirone, 1-(2-pyrimidinyl)piperazine (1-PP), occurs at higher circulating levels than buspirone itself and is known to act as a potent α 2-adrenergic receptor antagonist.
Cerebrovascular accident (stroke); Myocardial infarction (heart attack); Cardiomyopathy; Congestive heart failure; Bradycardia; Dysphoria; Hallucinations; Feelings of ...
Prazosin is active after taken by mouth and has a minimal effect on cardiac function due to its α 1-adrenergic receptor selectivity.When prazosin is started, however, heart rate and contractility can increase in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure.
A common metabolite of several azapirones including buspirone, gepirone, ipsapirone, revospirone, and tandospirone is 1-(2-pyrimidinyl)piperazine (1-PP). [ 47 ] [ 48 ] [ 49 ] 1-PP possesses 5-HT 1A partial agonist and α 2 -adrenergic antagonist actions and likely contributes overall mostly to side effects.
Desoxyn (methamphetamine hydrochloride) – used to treat attention deficit hyperactivity disorder and exogenous obesity; Dexedrine (dextroamphetamine sulfate) – used to treat attention deficit hyperactivity disorder and narcolepsy
Buspirone/testosterone (tentative brand name Lybridos) is a combination of buspirone, a 5-HT 1A receptor partial agonist, α 2-adrenergic receptor antagonist, and D 2 autoreceptor antagonist, [1] and testosterone, an androgen or androgen receptor agonist, which is under development by the pharmaceutical company Emotional Brain for the treatment of female sexual dysfunction.
Housing is famously cramped in the Asian financial hub of Hong Kong, thanks to sky-high property prices, but a single toilet and kitchen shared by four families would make for a challenging home ...
Tandospirone, sold under the brand name Sediel, is an anxiolytic and antidepressant medication used in Japan and China, where it is marketed by Dainippon Sumitomo Pharma.It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone.