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Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. [6]
Human leukocyte Interferon-alpha (HuIFN-alpha-Le) Multiferon Interferon beta 1a, liquid form: Rebif Interferon beta 1a, lyophilized: Avonex Interferon beta 1a, biogeneric (Iran) Cinnovex Interferon beta 1b: Betaseron / Betaferon Interferon gamma 1b: Actimmune PEGylated interferon alpha 2a: Pegasys PEGylated interferon alpha 2a (Egypt) Reiferon ...
ATC code L03 Immunostimulants is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
3440 15965 Ensembl ENSG00000188379 ENSMUSG00000078354 UniProt P01563 P01573 RefSeq (mRNA) NM_000605 NM_010503 RefSeq (protein) NP_000596 NP_034633 Location (UCSC) Chr 9: 21.38 – 21.39 Mb Chr 4: 88.6 – 88.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. Protein family Human interferon alpha-2 (IFNα2) is ...
They include interleukin-1 (IL-1), IL-6, IL-12, and IL-18, tumor necrosis factor alpha (TNF-α), interferon gamma (IFNγ), and granulocyte-macrophage colony stimulating factor (GM-CSF) and play an important role in mediating the innate immune response. Inflammatory cytokines are predominantly produced by and involved in the upregulation of ...
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human type I IFNs include many subtypes, such as interferons-α, -β, -ε, -κ, -ω, and -ζ.
Interferon alfa or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α), obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography.
The human interferon-gamma receptor complex consists the heterodimer of two chains: IFNGR1 and IFNGR2. [2] [3] In unstimulated cells, these subunits are not preassociated with each other but rather associate through their intracellular domains with inactive forms of specific Janus family kinases (Jak1 and Jak2). Jak1 and Jak2 constitutively ...