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Botulism is a rare and potentially fatal illness caused by botulinum ... and goats with some labeled for use in horses and mules as well as separate vaccines for mink ...
First Flight was a thoroughbred horse used in the production of the first botulism antitoxin. The horse was used as a research animal between 1978 and 1993 to produce antitoxin for military and civilian personnel. Until the 1990s, serum derived from First Flight was the only source of the antitoxin in the United States.
BAT is the only FDA-approved product available for treating botulism in adults, and for botulism in infants caused by botulinum toxins other than types A and B. BAT has been used to treat a case of type F infant botulism and, on a case-by-case basis, may be used for future cases of non-type A and non-type B infant botulism.
Since the 1960s, human tetanus immune globulin (TIG) has been used in the United States in unimmunized, vaccine-naive or incompletely immunized patients who have sustained wounds consistent with the development of tetanus. [13] The administration of horse antitoxin remains the only specific pharmacologic treatment available for botulism. [20]
Clostridium botulinum is a gram-positive, [1] rod-shaped, anaerobic, spore-forming, motile bacterium with the ability to produce botulinum toxin, which is a neurotoxin. [2] [3]C. botulinum is a diverse group of pathogenic bacteria.
Animal vaccination is the immunisation of a domestic, livestock or wild animal. [1] The practice is connected to veterinary medicine. [1] The first animal vaccine invented was for chicken cholera in 1879 by Louis Pasteur. [2]
Many of the vaccines that protect against biowarfare agents were first tested on humans in Operation Whitecoat. [4]According to USAMRIID, the Whitecoat operation contributed to vaccines approved by the U.S. Food and Drug Administration (FDA) for yellow fever and hepatitis, and investigational drugs for Q fever, Venezuelan equine encephalitis, Rift Valley fever, and tularemia.
Longer duration vaccines tend to be used in endemic regions of Australia where the disease is regularly encountered whereas shorter duration vaccines are used where the occurrence of botulism is sporadic. [9] The vaccine prevents the generation of toxins created by botulism which cause paralysis and protein and phosphorus deficiency causing ...
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