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The Epstein–Barr virus (EBV), formally called Human gammaherpesvirus 4, is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus. [2] Epstein–Barr virus (EBV) is the first identified oncogenic virus, or a virus that can cause cancer. EBV ...
There are several forms of Epstein–Barr virus (EBV) infection. These include asymptomatic infections, the primary infection, infectious mononucleosis, and the progression of asymptomatic or primary infections to: 1) any one of various Epstein–Barr virus-associated lymphoproliferative diseases such as chronic active EBV infection, EBV+ hemophagocytic lymphohistiocytosis, Burkitt's lymphoma ...
Infectious mononucleosis (IM, mono), also known as glandular fever, is an infection usually caused by the Epstein–Barr virus (EBV). [2] [3] Most people are infected by the virus as children, when the disease produces few or no symptoms. [2] In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and ...
Surprisingly, Epstein–Barr virus is a very common but relatively mild infection of Europeans. Why it can cause such a devastating illness in Africans is not fully understood, but reduced immunity to virus caused by malaria might be to blame. [56] Epstein–Barr virus is important in the history of viruses for being the first virus shown to ...
Achong, Anthony Epstein and Yvonne Barr discovered the first example of a human cancer-causing virus. [4] They published the discovery of the Epstein–Barr virus (EBV) in The Lancet on 28 March 1964. Achong's role in the discovery of EBV was to prepare and examine cultured cells prepared from Burkitt lymphoma samples by electron microscopy. [5 ...
Epstein was the first person to propose that Burkitt's lymphoma was a cancer caused by a virus. Upon hearing a lecture given by surgeon Denis Parsons Burkitt in 1961 about this newly described cancer, Epstein changed his research focus from cancer-causing viruses in chickens to searching for a viral origin of Burkitt's lymphoma. [22]
Yvonne Margaret Balding [2] [3] (née Barr; [2] 11 March 1932 – 13 February 2016) [3] was an Irish virologist who co-discovered the Epstein–Barr virus (EBV), [4] [5] which, because it identified a virus as a cause of cancer in humans, has been called "one of the 20th century's most significant scientific discoveries."
BZLF1 (BamHI Z fragment leftward open reading frame 1), also known as Zta, EB1, is an immediate-early viral gene of the Epstein–Barr virus (EBV) of the Herpes Virus Family, which induces cancers and infects primarily the B-cells of 95% of the human population. [1]