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Residual anhedonia that is not well targeted by serotonergic antidepressants is hypothesized to result from inhibition of dopamine release by activation of 5-HT 2C receptors in the striatum. [82] The response to reward in the medial orbitofrontal cortex (OFC) is attenuated in depression, while lateral OFC response is enhanced to punishment. The ...
Magnesium (Mg) is a mineral found naturally in the human body and in animal and plant-based foods, beverages, dietary supplements, and some medicines such as laxatives. [1] It is necessary for the functioning of every organ, for the makeup of teeth and bones, and for metabolic processes. [2]
The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]
Reports have suggested that certain antidepressants can sometimes have weight gain as a side effect. A study recently published in the Annals of Internal Medicine examined weight changes related ...
One theory to explain antidepressant-related weight gain is that psychotropic medications such as antidepressants can affect neurotransmitters involved in eating behavior, causing an increase in ...
Another study of over 600 young adults and children looked at the link between vitamin B12 levels and body mass index (BMI), with lower B12 levels resulting in higher body weight.
Certain antidepressants may cause emotional blunting, characterized by reduced intensity of both positive and negative emotions as well as symptoms of apathy, indifference, and amotivation. [ 82 ] [ 83 ] It may be experienced as either beneficial or detrimental depending on the situation. [ 84 ]
“The combination of body and cognitive changes is a major clue that a treatable cause such as B12 deficiency could be the issue,” he says. How vitamin B12 deficiency is detected
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