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Pyrimidine (C 4 H 4 N 2; / p ɪ ˈ r ɪ. m ɪ ˌ d iː n, p aɪ ˈ r ɪ. m ɪ ˌ d iː n /) is an aromatic, heterocyclic, organic compound similar to pyridine (C 5 H 5 N). [3] One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has nitrogen atoms at positions 1 and 3 in the ring.
Similarly, the simple-ring structure of cytosine, uracil, and thymine is derived of pyrimidine, so those three bases are called the pyrimidine bases. [ 6 ] Each of the base pairs in a typical double- helix DNA comprises a purine and a pyrimidine: either an A paired with a T or a C paired with a G.
Left: The structure of pyrimidine with the locants for ring atoms marked. Right : 5-Fluorouracil , a fluoropyrimidine formally named as 5-fluoro-1 H ,3 H -pyrimidine-2,4-dione Fluoropyrimidines are a general class organic compounds in which the substituent (s) around a pyrimidine ring include at least one fluorine atom.
Uridine (symbol U or Urd) is a glycosylated pyrimidine analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N 1-glycosidic bond.The analog is one of the five standard nucleosides which make up nucleic acids, the others being adenosine, thymidine, cytidine and guanosine.
Dihydrouridine (abbreviated as D, [1] DHU, or UH 2) is a pyrimidine nucleoside which is the result of adding two hydrogen atoms to a uridine, making it a fully saturated pyrimidine ring with no remaining double bonds.
Pyrimidone is the name given to either of two heterocyclic compounds with the formula C 4 H 4 N 2 O: 2-pyrimidone and 4-pyrimidone. The compounds can also be called 2-hydroxypyrimidine or 4-hydroxypyrimidine respectively, based on a substituted pyrimidine , or 1,3- diazine , ring.
[1] Pyrimidine de Novo pathway. Synthesis of pyrimidine nucleotides is a much simpler process. The formation of the pyrimidine ring begins with the conversion of Aspartate to N-Carbamoylaspartate by undergoing a condensation reaction with carbamoyl phosphate. Dihydroorotase and dihydroorotase dehydrogenase then converts N-Carbamoylaspartate to ...
Orotidine 5'-monophosphate (OMP), also known as orotidylic acid, is a pyrimidine nucleotide [1] which is the last intermediate in the biosynthesis of uridine monophosphate. [2] OMP is formed from orotate and phosphoribosyl pyrophosphate by the enzyme orotate phosphoribosyltransferase .