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In 1981, a paper by Gosselin estimated that the lethal dose is between 50 and 500 mg/kg. Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17]
Dextromethorphan, sold under the brand name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder .
Alaska House Bill No. 125 [2] placed regulations on who can sell and who can buy products that contain any level of dextromethorphan. The provider must check the identification of a person wishing to purchase dextromethorphan-containing products to verify that the purchaser is 18 years of age or older.
The maker of Robitussin cough syrup is recalling several lots of products containing honey due to contamination that could pose a serious risk to people with weakened immune systems. Haleon’s ...
The settlement covers Robitussin purchasers from Feb. 16, 2016 to the present. Payouts may total $1.50 to $4.75 per claim, depending on the number of claims. As much as $2.05 million, or 46% of ...
Some brand names include: Benylin, Sudafed, Robitussin and Vicks among others. [35] Most contain a number of active ingredients. [4] The Thai company Hatakabb produces the Takabb Anti-Cough Pill, which is a Chinese herbal medication. [36] Sudafed is a brand manufactured by McNeil Laboratories.
The dose of bupropion in the study was lower than the target dose recommended for clinical practice. [10] In this study, dextromethorphan/bupropion showed significantly greater improvement than bupropion alone in the first two weeks of treatment but not by week 6 of treatment in people with major depressive disorder.
Early 20th century "Frog In Your Throat" box, containing lozenges made of cubeb, tolu balsam, liquorice, white horehound and wild cherry extracts.. Candies to soothe the throat date back to 1000 BC in Egypt's Twentieth Dynasty, when they were made from honey flavored with citrus, herbs, and spices.
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