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  2. Glomerular filtration rate - Wikipedia

    en.wikipedia.org/wiki/Glomerular_filtration_rate

    The glomerular filtration rate is the flow rate of filtered fluid through the kidney. The creatinine clearance rate (C Cr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR. Creatinine clearance exceeds GFR due to creatinine secretion, [1] which can be blocked by ...

  3. Assessment of kidney function - Wikipedia

    en.wikipedia.org/wiki/Assessment_of_kidney_function

    The glomerular filtration rate (GFR) describes the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. [3] Creatinine clearance (C Cr) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.

  4. Chronic kidney disease - Wikipedia

    en.wikipedia.org/wiki/Chronic_kidney_disease

    The GFR is derived from the serum creatinine and is proportional to 1/creatinine, i.e. it is a reciprocal relationship; the higher the creatinine, the lower the GFR. It reflects one aspect of kidney function, how efficiently the glomeruli – the filtering units – work. The normal GFR is 90–120 ml/min.

  5. Nephrotic syndrome - Wikipedia

    en.wikipedia.org/wiki/Nephrotic_syndrome

    Under normal conditions a 24-hour urine sample should not exceed 80 milligrams or 10 milligrams per decilitre. [11] Hypoalbuminemia of less than 2.5 g/dL, [9] that exceeds the liver clearance level, that is, protein synthesis in the liver is insufficient to increase the low blood protein levels. Edema is thought to be caused by two mechanisms.

  6. Azotemia - Wikipedia

    en.wikipedia.org/wiki/Azotemia

    The BUN:Cr in prerenal azotemia is greater than 20. The reason for this lies in the mechanism of filtration of urea and creatinine. Renal Plasma Flow (RPF) is decreased due to hypoperfusion which results in a proportional decrease in Glomerular Filtration Rate (GFR). In turn, the decreased flow and pressure to the kidney will be sensed by ...

  7. Acute kidney injury - Wikipedia

    en.wikipedia.org/wiki/Acute_kidney_injury

    Injury: Two-fold increase in the serum creatinine, or GFR decrease by 50 percent, or urine output <0.5 mL/kg per hour for 12 hours. Failure: Three-fold increase in the serum creatinine, or GFR decrease by 75 percent, or urine output of <0.3 mL/kg per hour for 24 hours, or no urine output (anuria) for 12 hours.

  8. Creatinine - Wikipedia

    en.wikipedia.org/wiki/Creatinine

    Algorithms to estimate GFR from creatinine concentration and other parameters are discussed in the renal function article. Unfortunately, the MDRD Study equation was developed in people with chronic kidney disease, and its major limitations are imprecision and systematic underestimation of measured GFR (bias) at higher/normal values. [20]

  9. Kidney failure - Wikipedia

    en.wikipedia.org/wiki/Kidney_failure

    Diagnosis of acute failure is often based on a combination of factors such as decreased urine production or increased serum creatinine. [3] Diagnosis of chronic failure is based on a glomerular filtration rate (GFR) of less than 15 or the need for renal replacement therapy. [1] It is also equivalent to stage 5 chronic kidney disease. [1]

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