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Nonetheless, a study in 2013 reported that cSLE patients with lupus nephritis had a 19-fold higher mortality rate while aSLE patients with lupus nephritis had an 8-fold higher mortality rate than their respective age-matched populations [7] [82] and a study in 2020 suggested that the survival rate of lupus nephritis in children and adults has ...
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE) and childhood-onset systemic lupus erythematosus which is a more severe form of SLE that develops in children up to 18 years old; both are autoimmune diseases.
Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. [1] Symptoms vary among people and may be mild to severe. [1]
The cause of diffuse proliferative glomerulonephritis (DPGN) depends on the severity of the disease. DPGN is a secondary disease, in that a disease that a patient already has causes DPGN to occur. The most common associated disease of DPGN is severe systemic lupus erythematosus(SLE). [4] Specifically, Lupus nephritis class IV. [5]
Prognosis is good. A less common target antigen in lupus nephritis is NCAM1. [10] Semaphorin3B predominates in children, esp <2 years old. there can be a family history of MN in these patients, it frequently causes progressive disease and it can recur in kidney transplants. Protocadherin 7 (PCDH7) in 2020.
Acute proliferative glomerulonephritis is a disorder of the small blood vessels of the kidney.It is a common complication of bacterial infections, typically skin infection by Streptococcus bacteria types 12, 4 and 1 but also after streptococcal pharyngitis, for which it is also known as postinfectious glomerulonephritis (PIGN) or poststreptococcal glomerulonephritis (PSGN). [4]
Childhood-onset nephrotic syndrome is a kidney disorder characterized by severe proteinuria (excess proteins in the urine), hypoalbuminemia (low albumin levels in the blood), and edema (swelling) that affects approximately 2-7 per 100,000 children under 18 years of age annually.
Nephrotic syndrome can be associated with a series of complications that can affect an individual's health and quality of life: [15] Thromboembolic disorders: particularly those caused by a decrease in blood antithrombin III levels due to leakage. Antithrombin III counteracts the action of thrombin. Thrombosis usually occurs in the kidney veins ...