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Deafness in animals can occur as either unilateral (one ear affected) or bilateral (both ears affected). This occurrence of either type of deafness seems to be relatively the same in both mixed-breed animals and pure-breed animals. [5] Research has found a significant association between deafness in dogs and the pigment genes piebald and merle ...
Deafness can occur in white cats with yellow, green or blue irises, although it is mostly likely in white cats with blue irises. [4] In white cats with one blue eye and one eye of a different color (odd-eyed cats), deafness is more likely to affect the ear on the blue-eyed side. [1] Approximately 50% of white cats have one or two blue eyes. [5]
Canine cancer treatment has become an accepted clinical practice and access to treatment for owners has widely expanded recently. [2] Cancer-targeting drugs most commonly function to inhibit excessive cell proliferation by attacking the replicating cells. [6] There is one canine tumor vaccine approved by the USDA, for preventing canine melanoma ...
Deafness* in dogs can be either acquired or congenital. Predisposing factors for acquired deafness include chronic infection, use of certain drugs, and most commonly, age-related changes in the cochlea. Congenital deafness can be genetic, seen sometimes in dogs with merle or white coats, or caused by in utero damage from infections or toxins. [77]
An example is sodium thiosulfate, which the US FDA approved in 2022 to minimise the risk of ototoxicity and hearing loss in newborn, child, and adolescent cancer patients receiving cisplatin. [ 29 ] [ 30 ] [ 31 ] Other agents being investigated for their potential to reduce ototoxicity include D-methionine and L-N-acetylcysteine . [ 3 ]
Mutations in the gene encoding otoferlin are a cause of a neurosensory nonsyndromic recessive deafness, DFNB9.The diagnosis is identified by molecular genetic testing.. In October 2023 two small clinical trials for a gene therapy restoring the defective Otoferlin via an adeno-associated virus (AAVs) have been announced.
Ototoxicity-induced hearing loss typically impacts the high frequency range, affecting above 8000 Hz prior to impacting frequencies below. [8] There is not global consensus on measuring severity of ototoxicity-induced hearing loss as there are many criteria available to define and measure ototoxicity-induced hearing loss.
They may cause symptoms, sickness or the death of the animal. Some diseases are symptomatic in one cat but asymptomatic in others. Feline diseases are often opportunistic and tend to be more serious in cats that already have concurrent sicknesses. Some of these can be treated and the animal can have a complete recovery.