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The AP-1 transcription factor also has been shown to be involved in breast cancer cell growth through multiple mechanisms, including regulation of cyclin D1, E2F factors and their target genes. c-Jun, which is one of the AP-1 subunits, regulates the growth of breast cancer cells.
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...
These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [6]
It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts ...
16477 Ensembl ENSG00000171223 ENSMUSG00000052837 UniProt P17275 P09450 RefSeq (mRNA) NM_002229 NM_008416 RefSeq (protein) NP_002220 NP_032442 Location (UCSC) Chr 19: 12.79 – 12.79 Mb Chr 8: 85.7 – 85.71 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. Transcription factor jun-B is a transcription ...
She also had to have a blood transfusion, and both those factors made it difficult to find a match to a kidney donor. In 2016, Looney went on dialysis, a procedure to help remove waste and extra ...
An animal testing laboratory at Elon Musk's Neuralink brain technology company was found to have "objectionable conditions or practices" by the Food and Drug Administration, which cited the ...
These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [5]