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Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
The nortriptyline group experienced moderate weight gain. However, antidepressants don’t affect everyone equally, so there could still be a link between Lexapro and weight changes or other SSRIs ...
Here are links to possibly useful sources of information about Nortriptyline. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC
A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine.
TCA overdose may occur by accident or purposefully in an attempt to cause death. [2] The toxic dose depends on the specific TCA. [2] Most are non-toxic at less than 5 mg/kg except for desipramine, nortriptyline, and trimipramine, which are generally non-toxic at less than 2.5 mg/kg. [5] [2] In small children one or two pills can be fatal. [6]
There’s good reason to work on putting your insomnia to sleep: The sleep disorder is associated with an increased risk of hypertension, diabetes, obesity, depression, heart attack, and stroke ...
A new study reveals a shocking potential cause for insomnia.
When a person struggles to fall asleep or stay asleep with no obvious cause , it is referred to as insomnia, [2] which is the most common sleep disorder. [3] Others include sleep apnea , narcolepsy and hypersomnia (excessive sleepiness at inappropriate times), sleeping sickness (disruption of sleep cycle due to infection), sleepwalking , and ...