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A dorsal root ganglion (or spinal ganglion; also known as a posterior root ganglion [1]) is a cluster of neurons (a ganglion) in a dorsal root of a spinal nerve. The cell bodies of sensory neurons known as first-order neurons are located in the dorsal root ganglia. [2] The axons of dorsal root ganglion neurons are known as afferents.
The root emerges from the posterior part of the spinal cord and travels to the dorsal root ganglion. The dorsal root ganglia contain the pseudo-unipolar cell bodies of the nerve fibres which travel from the ganglia through the root into the spinal cord. The lateral division of the dorsal root contains lightly myelinated and unmyelinated fibres ...
Sodium voltage-gated channel alpha subunit 9 (also Na v 1.7) is a sodium ion channel that, in humans, is encoded by the SCN9A gene. [5] [6] [7] It is usually expressed at high levels in two types of neurons: the nociceptive (pain) neurons at the dorsal root ganglion (DRG) and trigeminal ganglion; and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.
Just outside the spinal cord, thousands of afferent neuronal cell bodies are aggregated in a swelling in the dorsal root known as the dorsal root ganglion. [1] [2] All of the axons in the dorsal root, which contains afferent nerve fibers, are used in the transduction of somatosensory information.
The dorsal rami provide motor innervation to the deep (a.k.a. intrinsic or true) muscles of the back, and sensory innervation to the skin of the posterior portion of the head, neck and back. [1] A spinal nerve splits within the intervertebral foramen to form a dorsal ramus and a ventral ramus. The dorsal ramus then turns to course posterior ...
The body is situated in the dorsal root ganglion, with one axon traveling peripherally to tissue, and one traveling into the dorsal column. On the right is a bipolar neuron. When an action potential is generated by a mechanoreceptor in the tissue, the action potential will travel along the peripheral axon of the first-order neuron.
The posterior (dorsal) root ganglion is situated within the IVF. [2]: 425 The adipose tissue of the spinal epidural space extends into the IVF. The spinal dura mater extends laterally with each departing spinal nerve, reaching into the IVF. [2]: 453 Transforaminal ligaments (when present) extend through the IFV. [3]
Na v 1.8 is expressed specifically in the dorsal root ganglion (DRG), in unmyelinated, small-diameter sensory neurons called C-fibres, and is involved in nociception. [ 9 ] [ 10 ] C-fibres can be activated by noxious thermal or mechanical stimuli and thus can carry pain messages.