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The family of sodium channels has 9 known members, with amino acid identity >50% in the trans-membrane segments and extracellular loop regions. A standardized nomenclature for sodium channels is currently used and is maintained by the IUPHAR. [11] The proteins of these channels are named Na v 1.1 through Na v 1.9.
Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the sodium ion Na +. They are the main channels involved in action potential of excitable cells.
Deactivation is the return of an ion channel to its closed conformation. For voltage-gated channels this occurs when the voltage differential that originally caused the channel to open returns to its resting value. [31] In voltage-gated sodium channels, deactivation is necessary to recover from inactivation. [26]
20264 Ensembl ENSG00000185313 ENSMUSG00000034533 UniProt Q9Y5Y9 Q6QIY3 RefSeq (mRNA) NM_001293306 NM_001293307 NM_006514 NM_001205321 NM_009134 RefSeq (protein) NP_001280235 NP_001280236 NP_006505 NP_001192250 NP_033160 Location (UCSC) Chr 3: 38.7 – 38.82 Mb Chr 9: 119.44 – 119.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Na v 1.8 is a sodium ion channel subtype that in ...
A positively charged region between the III and IV domains of sodium channels is thought to act in a similar way. [9] The essential region for inactivation in sodium channels is four amino acid sequence made up of isoleucine, phenylalanine, methionine and threonine (IFMT). [13] The T and F interact directly with the docking site in the channel ...
Voltage-gated sodium channel Familial hemiplegic migraine: various Associated with one particular disabling form of fibromyalgia [4] Voltage-gated sodium channel Hyperkalemic periodic paralysis: Voltage-gated sodium channel Hypokalemic periodic paralysis: Voltage-gated sodium channel or. voltage-dependent calcium channel (calciumopathy)
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In hypokalemic periodic paralysis, arginine residues making up the voltage sensor of Na v 1.4 are mutated. The voltage sensor comprises the S4 alpha helix of each of the four transmembrane domains (I-IV) of the protein, and contains basic residues that only allow entry of the positive sodium ions at appropriate membrane voltages by blocking or opening the channel pore.