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Arginine alpha-ketoglutarate (AAKG) is a salt of the amino acid arginine and alpha-ketoglutaric acid. It is marketed as a bodybuilding supplement. [1] Peer-reviewed studies have found no increase in muscle protein synthesis or improvement in muscle strength from use of AAKG as a dietary supplement. [1] [2] [3]
Outside of the citric acid cycle, α-ketoglutarate is made by a) the enzymes isocitrate dehydrogenase 1 or 2 which remove a carboxy group from isocitrate by oxidative decarboxylation to form α-ketoglutarate; b) glutaminolysis in which the enzyme glutaminase removes the amino group (i.e., −NH 2) from glutamine to form glutamate which is ...
Arginine (sometimes as complexes like arginine alpha-ketoglutarate), is also commonly used as a nitric oxide precursor and supposed booster of growth hormone and IGF-1 release, though studies have shown limited benefits, and generally at higher doses than are present in typical pre-workout products. [35] [36]
The Autoimmune Protocol (AIP) diet is an elimination diet designed to help reduce inflammation, manage symptoms and improve quality of life for people with autoimmune diseases.
Experts explain what seed oils are, their benefits, and why they get so much hate. Wellness influencers say yes, but their claims are slippery at best. Experts explain what seed oils are, their ...
The α-ketoglutarate family of amino acid synthesis (synthesis of glutamate, glutamine, proline and arginine) begins with α-ketoglutarate, an intermediate in the Citric Acid Cycle. The concentration of α-ketoglutarate is dependent on the activity and metabolism within the cell along with the regulation of enzymatic activity.
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