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The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.
Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Conivaptan, sold under the brand name Vaprisol, is a non-peptide inhibitor of the receptor for anti-diuretic hormone, also called vasopressin. It was approved in 2004 for hyponatremia (low blood sodium levels).
Vasopressin receptor antagonists include the new class of "vaptan drugs" such as conivaptan, tolvaptan, mozavaptan ... Commons Attribution-ShareAlike 4.0 ...
This page was last edited on 3 December 2021, at 17:59 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
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554 12000 Ensembl ENSG00000126895 ENSMUSG00000031390 UniProt P30518 O88721 RefSeq (mRNA) NM_000054 NM_001146151 NM_001276298 NM_001276299 NM_019404 RefSeq (protein) NP_000045 NP_001139623 NP_001263227 NP_001263228 NP_062277 Location (UCSC) Chr X: 153.9 – 153.91 Mb Chr X: 72.94 – 72.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Vasopressin receptor 2 (V2R), or arginine ...
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