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In August 2020, the U.S. Food and Drug Administration (FDA) became aware of nitrosamine impurities in certain samples of rifampin. [61] The FDA and manufacturers are investigating the origin of these impurities in rifampin, and the agency is developing testing methods for regulators and industry to detect the 1-methyl-4-nitrosopiperazine (MNP ...
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
Italy became a republic after the 1946 Italian institutional referendum [109] held on 2 June, a day celebrated since as Festa della Repubblica. This was the first time women voted nationally. [110] Victor Emmanuel III's son, Umberto II, was forced to abdicate. The Republican Constitution was approved in 1948.
All the other Italian states remained independent, with the most powerful being the Venetian Republic, the Medici's Duchy of Tuscany, the Savoyard state, the Republic of Genoa, and the Papal States. The Gonzaga in Mantua, the Este in Modena and Ferrara and the Farnese in Parma and Piacenza continued to be important dynasties.
The referendum at the origin of the Italian republic was, however, the subject of some controversy, not least because of some contested results and because of a geographical divide between the North, where the Republic won a clear majority, and the South, where the monarchists were in a majority. [32]
The Constitution of the Italian Republic is the result of the work of the Constituent Assembly, which was formed by the representatives of all the anti-fascist forces that contributed to the defeat of nazis and the fascist forces during the Italian Civil War. [1] Article 1 of the Italian constitution states: [2]
The Italian Republican Party (Italian: Partito Repubblicano Italiano, PRI) is a political party in Italy established in 1895, which makes it the oldest political party still active in the country. The PRI identifies with 19th-century classical radicalism , [ 1 ] as well as Mazzinianism , [ 2 ] [ 3 ] and its modern incarnation is associated with ...
The politics of Italy are conducted through a parliamentary republic with a multi-party system. Italy has been a democratic republic since 2 June 1946, when the monarchy was abolished by popular referendum and a constituent assembly, formed by the representatives of all the anti-fascist forces that contributed to the defeat of Nazi and Fascist forces during the liberation of Italy, was elected ...