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12351 Ensembl ENSG00000167434 ENSMUSG00000000805 UniProt P22748 Q64444 RefSeq (mRNA) NM_000717 NM_007607 RefSeq (protein) NP_000708 NP_031633 Location (UCSC) Chr 17: 60.15 – 60.17 Mb Chr 11: 84.85 – 84.86 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene. Function Carbonic anhydrases (CAs) are a large ...
Carbonic anhydrase helps maintain acid–base homeostasis, regulate pH, and fluid balance. Depending on its location, the role of the enzyme changes slightly. For example, carbonic anhydrase produces acid in the stomach lining. In the kidney, the control of bicarbonate ions influences the water content of the cell.
The reaction catalyzed by CA1 is the same as other carbonic anhydrase family proteins: + (in tissues - high CO 2 concentration) [9]. The CA1-catalyzed reaction has a relatively low reaction affinity (Km) of 4.0 mM for CO 2, [7] [10] turnover number (Kcat) of 2 × 10 5 s −1, and catalytic efficiency (Kcat/Km) of 5 × 10 7 M −1 s −1 comparing to other isozymes of the α-CA family of ...
Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical use has been established as anti- glaucoma agents, diuretics , antiepileptics , in the management of mountain sickness , gastric and duodenal ulcers , idiopathic intracranial hypertension , neurological disorders , or ...
Carbonic anhydrase catalyzes the conversion of carbon dioxide and water into carbonic acid. This molecule breaks down into bicarbonate and hydrogen ions. This break down process occurs in red blood cells. Ultimately, the concentration of bicarbonate ions in the bloodstream affects the formation of the protein carbaminohemoglobin in the body. [11]
770 12348 Ensembl ENSG00000063180 ENSMUSG00000003273 UniProt O75493 O70354 RefSeq (mRNA) NM_001217 NM_009800 NM_001368349 RefSeq (protein) NP_001208 NP_033930 NP_001355278 Location (UCSC) Chr 19: 48.64 – 48.65 Mb Chr 7: 45.35 – 45.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carbonic anhydrase-related protein 11 is a protein that in humans is encoded by the CA11 gene ...
12352 Ensembl ENSG00000174990 ENSMUSG00000025317 UniProt P35218 P23589 RefSeq (mRNA) NM_001739 NM_001367225 NM_007608 RefSeq (protein) NP_001730 NP_031634 Location (UCSC) Chr 16: 87.88 – 87.94 Mb Chr 8: 122.64 – 122.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carbonic anhydrase 5A, mitochondrial is a protein that in humans is encoded by the CA5A gene. Function Carbonic ...
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification , acid-base balance, bone resorption , and the formation of aqueous humor , cerebrospinal fluid , saliva, and gastric acid.