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Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
FE Na is calculated in two parts—figuring out how much sodium is excreted in the urine, and then finding its ratio to the total amount of sodium that passed through (aka "filtered by") the kidney. [citation needed] First, the actual amount of sodium excreted is calculated by multiplying the urine sodium concentration by the urinary flow rate ...
Furosemide is a known ototoxic agent generally causing transient hearing loss but can be permanent. Reported cases of furosemide-induced hearing loss appeared to be associated with rapid intravenous administration, high dosages, concomitant renal disease, and coadministration with other ototoxic medication.
Medication underdosing occurs commonly when physicians write prescriptions that are correct for a certain time, but fails to increase the dose as the patient needs (i.e. weight-based dosing in children, or increasing dose of chemotherapy drugs if a patient's condition worsens). [5]
For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.
The company experienced a system issue that affected multiple products including account withdrawals, peer-to-peer payment service Venmo, online checkout and crypto. PayPal said the issue, which ...
This medication works by decreasing the amount of glucose your body absorbs from food and the amount of glucose made in your liver while reducing blood glucose overall.
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