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Mechanism of non-amplifying and self-amplifying mRNA vaccines. The initial mRNA vaccines use a non-amplifying mRNA construct. [64] Non-amplifying mRNA has only one open reading frame that codes for the antigen of interest. [97] The total amount of mRNA available to the cell is equal to the amount delivered by the vaccine.
National regulatory authorities have granted full or emergency use authorizations for 40 COVID-19 vaccines.. Ten vaccines have been approved for emergency or full use by at least one stringent regulatory authority recognized by the World Health Organization (WHO): Pfizer–BioNTech, Oxford–AstraZeneca, Sinopharm BIBP, Moderna, Janssen, CoronaVac, Covaxin, Novavax, Convidecia, and Sanofi ...
Political leanings are reflected in vaccine hesitancy. Early in the pandemic, before vaccines were available, a poll conducted May 20–21, 2020, found that 44% of Republicans and 19% of Democrats believed a debunked conspiracy theory that Bill Gates was plotting to use a COVID-19 vaccine to inject microchips into the population. [191]
Moderna’s unnamed version of the vaccine for children 6 months to 11 years has been authorized for emergency use. Single pediatric doses contain 25 μg of mRNA.
In the case of the Pfizer vaccine, the list is quite short: The only contraindication listed by the FDA is a “known history of a severe allergic reaction (e.g., anaphylaxis) to any component of ...
Moderna CEO Stéphane Bancel says the company is working on a vaccine formula and packaging that will make it easier to use mNRA technology. Next-generation mRNA vaccines will be easier to use ...
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