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In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
It is calculated using the LD50 or LC50. [1] The Occupational Safety and Health Administration (OSHA) regulation (1910.134(b)) defines the term as "an atmosphere that poses an immediate threat to life, would cause irreversible adverse health effects, or would impair an individual's ability to escape from a dangerous atmosphere."
In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation. Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die. The lethal ...
The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]
In toxicology, the median toxic dose (TD 50) of a drug or toxin is the dose at which toxicity occurs in 50% of cases. [1]: 73 The type of toxicity should be specified for this value to have meaning for practical purposes.
Dermal LD50 Up to and including 200 mg/kg From 200 to 2000 mg/kg From 2000 to 20,000 mg/kg Greater than 20,000 mg/kg Eye Effects Corrosive; corneal opacity not reversible within 7 days Corneal opacity reversible within 7 days; irritation persisting for 7 days No corneal opacity; irritation reversible within 7 days No irritation. Skin Effects
WASHINGTON (Reuters) -The Justice Department late on Wednesday asked a U.S. appeals court to reject an emergency bid by TikTok to temporarily block a law that would require its Chinese parent ...
The LD50 of potassium cyanide in the presence of both nitrite and thiosulfate is 52 mg/kg with a protective index of 4.73. Since the protective index is higher for the simultaneous use of nitrite and thiosulfate, the two chemicals constitute the antidote against cyanide intoxication.