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Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. [5] It is an important regulator of cardiac development [ 6 ] and a marker of hippocampal neural stem cells . [ 7 ] [ 8 ]
Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [5]
The protein kinase domain is 330 amino acids long and is located near the N-terminus of the protein. [ 23 ] [ 24 ] In addition to its kinase domain, HIPK2 has two nuclear localization signals, [ 25 ] a SUMO interaction motif, [ 25 ] an auto-inhibitory domain [ 23 ] a transcriptional co-repression domain, [ 13 ] and several interaction domains ...
The Invertebrate genome contains 8-10 of is homeotic genes in only one complex, while Vertebrates have duplicated the Hox complex and have four clusters. Changes in the expression and functionality of individual genes result in various morphology as seen in arthropods. The diversity found between the five groups of arthropods is a result of ...
The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox
3975 16869 Ensembl ENSG00000273706 ENSG00000274577 ENSMUSG00000018698 UniProt P48742 Q58F18 P63006 RefSeq (mRNA) NM_005568 NM_008498 RefSeq (protein) NP_005559 NP_005559.2 NP_032524 Location (UCSC) Chr 17: 36.94 – 36.94 Mb Chr 11: 84.41 – 84.42 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. This gene encodes ...
engrailed is a homeodomain transcription factor [1] involved in many aspects of multicellular development. First known for its role in arthropod embryological development, working in consort with the Hox genes, engrailed has been found to be important in other areas of development.