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Spironolactone has shown no significant effect on levels of testosterone, estradiol, luteinizing hormone, and follicle-stimulating hormone in men. [ 146 ] [ 78 ] No or only small changes in cortisol levels have been observed in clinical studies with spironolactone.
Side effects of spironolactone which may be indicative of hyperkalemia and if persistent could justify serum potassium testing include nausea, fatigue, and particularly muscle weakness. [63] Notably, non-use of routine potassium monitoring with spironolactone in young women would reduce costs associated with its use. [63]
And because PCOS affects many hormones (example: estrogen) that are responsible for a variety of bodily functions, women with PCOS may also find it hard to become pregnant. ... Spironolactone is ...
Spirolactones are a class of functional group in organic chemistry featuring a cyclic ester attached spiro to another ring system. The name is also used to refer to a class of synthetic steroids, called steroid-17α-spirolactones, 17α-spirolactosteroids, or simply 17α-spirolactones, which feature their spirolactone group at the C17α position.
Androgenetic alopecia is caused by a combination of factors including genetic predisposition and the effects of male sex hormones called androgens. ... other medications like spironolactone may be ...
Spironolactone reduces the amount of androgen hormones in your body, which cuts down sebum production. Its effects on hormones are so pronounced that it is not recommended for treating acne in men ...
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Endocrine-disrupting chemicals affect hormones, which are chemicals that play the important role of carrying messages throughout your body to coordinate different functions in organs, skin ...