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Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion.It may also be regarded as the sodium salt of periodic acid.Like many periodates, it can exist in two different forms: sodium metaperiodate (formula NaIO 4) and sodium orthoperiodate (normally Na 2 H 3 IO 6, but sometimes the fully reacted salt Na 5 IO 6).
Periodate (/ p ə ˈ r aɪ. ə d eɪ t / pə-RY-ə-dayt) is an anion composed of iodine and oxygen. It is one of a number of oxyanions of iodine and is the highest in the series, with iodine existing in oxidation state +7.
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Periodic acid (/ ˌ p ɜːr aɪ ˈ ɒ d ɪ k / per-eye-OD-ik) is the highest oxoacid of iodine, in which the iodine exists in oxidation state +7. It can exist in two forms: orthoperiodic acid, with the chemical formula H 5 IO 6, and metaperiodic acid, which has the formula HIO 4.
Sodium periodate oxidizes the sialic acids on glycoproteins to aldehydes to form these stable linkages at pH 4–6. Polyclonal antibodies are heavily glycosylated, and because glycosylation does not interfere with the antibody activity, biotinylating the glycosyl groups is an ideal strategy to generate biotinylated antibodies.
Sodium arsenate – H 24 Na 3 AsO 16; Sodium azide – NaN 3; Sodium bicarbonate – NaHCO 3; Sodium biselenide – NaSeH; Sodium bisulfate – NaHSO 4; Sodium bisulfite – NaHSO 3; Sodium borate – Na 2 B 4 O 7; Sodium borohydride – NaBH 4; Sodium bromate – NaBrO 3; Sodium bromide – NaBr; Sodium bromite – NaBrO 2; Sodium carbide ...
Strong acids/bases (nitric acid, sodium hydroxide), calcium oxide, anhydrous zinc chloride can be corrosive GHS05: Corrosive Explosives, divisions 1.5, 1.6; Flammable gases, category 2; Self-reactive substances and mixtures, type G (see HAZMAT Class 4 Flammable solids) Organic peroxides, type G; no pictogram required
The development of the Lemieux–Johnson oxidation was preceded by an analogous process, developed by Lemieux and Ernst Von Rudloff (sometimes called the Lemieux-Von Rudloff reaction), which used an aqueous solution of sodium periodate with a low (catalytic) concentration of potassium permanganate. [7]