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Conjugated estrogens/medroxyprogesterone acetate (CEs/MPA), sold under the brand names Prempro and Premphase, is a combination product of conjugated equine estrogens (Premarin), an estrogen collected from horse urine, and medroxyprogesterone acetate (Provera), a progestogen, which is used in menopausal hormone therapy for the treatment of menopausal symptoms.
Medroxyprogesterone acetate (MPA), also known as depot medroxyprogesterone acetate (DMPA) in injectable form and sold under the brand name Depo-Provera among others, is a hormonal medication of the progestin type. [10] [4] It is used as a method of birth control and as a part of menopausal hormone therapy.
Major brand names of CEEs in combination with medroxyprogesterone acetate include Prempro and Premphase in the United States, Premplus in Canada, Premique in the United Kingdom and Ireland, Premia in Australia and New Zealand, and Premelle in South Africa.
Conjugated estrogens and medroxyprogesterone acetate (Premphase (Premarin, Cycrin 14/14), Premphase 14/14, Prempro ... Estradiol and norethisterone acetate ...
Medroxyprogesterone acetate (Amen, Curretab, Cycrin, Provera) – 2.5 mg, 5 mg, 10 mg Megestrol acetate (Megace) – 20 mg, 40 mg – approved specifically for the treatment of breast and endometrial cancer [ 46 ] and for the treatment of anorexia , cachexia , and weight loss in patients with AIDS Tooltip acquired immunodeficiency syndrome [ 47 ]
Quinestrol/quingestanol acetate (Unovis) For menopausal hormone therapy and/or gynecological disorders: Conjugated estrogens/medrogestone (Presomen) Conjugated estrogens/medroxyprogesterone acetate (Prempro, Premphase) Conjugated estrogens/norgestrel (Prempak-C) Estradiol/drospirenone (Angeliq) Estradiol/dydrogesterone (Femoston)
The WHI studies used one type of estrogen supplement, a high oral dose of conjugated estrogens (Premarin alone and with medroxyprogesterone acetate as Prempro). [10] In a study by the NIH, esterified estrogens were not proven to pose the same risks to health as conjugated estrogens.
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. [ 2 ] [ 3 ] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6α position.
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