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Viral-induced dilated cardiomyopathy can be characterized using different methods. A 2011 study showed in coxsackievirus infected heart proteome , increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes can be observed suggesting they could be characteristic in enteroviral cardiomyopathy.
Viral cardiomyopathy occurs when viral infections cause myocarditis with a resulting thickening of the myocardium and dilation of the ventricles. These viruses include Coxsackie B and adenovirus, echoviruses, influenza H1N1, Epstein–Barr virus, rubella (German measles virus), varicella (chickenpox virus), mumps, measles, parvoviruses, yellow fever, dengue fever, polio, rabies, and the ...
Myocarditis is defined as inflammation of the myocardium. Myocarditis can progress to inflammatory cardiomyopathy when there are associated ventricular remodeling and cardiac dysfunction due to chronic inflammation. [6] [7] Symptoms can include shortness of breath, chest pain, decreased ability to exercise, and an irregular heartbeat. [1]
Treatment depends on the type of cardiomyopathy and the severity of symptoms. [5] Treatments may include lifestyle changes, medications, or surgery. [5] Surgery may include a ventricular assist device or heart transplant. [5] In 2015 cardiomyopathy and myocarditis affected 2.5 million people. [6]
As of 2008, there is no well-accepted treatment for the Coxsackie B group of viruses. [1] Palliative care is available, however, and patients with chest pain or stiffness of the neck should be examined for signs of cardiac or central nervous system involvement, respectively. Some measure of prevention can usually be achieved by basic sanitation ...
Coxsackievirus B4 is one of the six serotypes found in Group B and is a positive sense, single-stranded, non-enveloped RNA virus. Its genome is linear and is 7,293 nucleotides in length with both a 5’ and 3’ untranslated region and encodes its own 3’ poly-A tail.
Or, it may be the late sequelae of acute viral myocarditis, such as with Coxsackie B virus and other enteroviruses [14] possibly mediated through an immunologic mechanism. [15] Specific autoantibodies are detectable in some cases. [16] Other causes include: Chagas disease, due to Trypanosoma cruzi.
Pericarditis may be caused by viral, bacterial, or fungal infection. In the developing world the bacterial disease tuberculosis is a common cause, whereas in the developed world viruses are believed to be the cause of about 85% of cases. [6] Viral causes include coxsackievirus, herpesvirus, mumps virus, and HIV among others. [4]