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Hypoadrenocorticism is typically a disease of young to middle-aged female dogs, although Standard Poodles and Bearded Collies of both sexes are prone to the condition. [38] Hypoadrenocorticism is an inherited disease in the following breeds (and therefore a higher proportion of dogs within these breeds are affected, compared to other breeds): [39]
Dogs are ten times more likely to be infected than humans. The disease in dogs can affect the eyes, brain, lungs, skin, or bones. [15] Histoplasmosis* is a fungal disease caused by Histoplasma capsulatum that affects both dogs and humans. The disease in dogs usually affects the lungs and small intestine. [16]
These symptoms may develop over a few months preceding the onset of SARDS. [4] Clinical signs and disease progression vary markedly among individual animals, depending on the number and type of hormones that are increased, the degree of hormone elevation, and the age of the dog.
A dog with degenerative myelopathy often stands with its legs close together and may not correct an unusual foot position due to a lack of conscious proprioception. Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy, is an incurable, progressive disease of the canine spinal cord that is similar in many ways to amyotrophic lateral sclerosis (ALS).
Fraley syndrome is a condition where the superior infundibulum of the upper calyx of the kidney is obstructed by the crossing renal (upper or middle section) artery branch, causing distension and dilatation of the calyx and presenting clinically as haematuria and nephralgia (ipsilateral flank pain).
A study of 66 dogs with Cushing's found 91% of dogs to have either polyuria or polydipsia, 79% to have polyphagia, and 77% to have alopecia. [ 4 ] Signs of ectopic adrenocorticotropic hormone secretion that accompany the rapidly progressing physical changes are high plasma levels of adrenocorticotropic hormones and cortisol alongside hypokalaemia .
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Either a minor calyx in the kidney, a conglomeration of two or three minor calyces to form a major calyx, or the Calyx of Held, a particularly large synapse in the mammalian auditory central nervous system, named by H. Held in his 1893 article Die centrale Gehörleitung, [3] due to its flower-petal-like shape.