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These adverse effects are believed to be due to the neurotoxic effects of repeated withdrawal from alcohol on aberrant neuronal plasticity and cortical damage. Repeated periods of acute intoxication followed by acute detoxification has profound effects on the brain and is associated with an increased risk of seizures as well as cognitive deficits.
Hippuric acid has long been used as an indicator of toluene exposure; [14] however, there appears to be some doubt about its validity. [15] There is significant endogenous hippuric acid production by humans; which shows inter- and intra-individual variation influenced by factors such as diet, medical treatment, alcohol consumption, etc. [15] This suggests that hippuric acid may be an ...
Alcohol inhalation is a method of administering alcohol directly into the respiratory system, with aid of a vaporizing or nebulizing device or bag. It is chiefly applied for recreational use, when it is also referred to as alcohol smoking, but it has medical applications for testing on laboratory rats, and treatment of pulmonary edema and viral pneumonia.
[1] Alcohol detoxification (also known as detox) is the abrupt cessation of alcohol intake in individuals that have alcohol use disorder. This process is often coupled with substitution of drugs that have effects similar to the effects of alcohol in order to lessen the symptoms of alcohol withdrawal. When withdrawal does occur, it results in ...
[1] Approximately 3 percent of people who are alcohol dependent experience psychosis during acute intoxication or withdrawal. Alcohol-related psychosis may manifest itself through a kindling mechanism. The mechanism of alcohol-related psychosis is due to distortions to neuronal membranes, gene expression, as well as thiamine deficiency. It is ...
Alcohol, sometimes referred to by the chemical name ethanol, is a depressant drug that is the active ingredient in drinks such as beer, wine, and distilled spirits (hard liquor). [11] It is one of the oldest and most commonly consumed recreational drugs, causing the characteristic effects of alcohol intoxication ("drunkenness"). [12]
Meza’s new analysis, published Dec. 1 in JAMA Health Forum, shows that while people ages 40 through 64 smoke the most, Americans 65 and above are picking up the habit in a way nobody else is ...
Clomethiazole is particularly toxic and dangerous if overdosed and is potentially fatal. Alcohol multiplies the effect. As the drug can be fatal in high doses, prescribing clomethiazole outside of a controlled environment, for example a hospital, is not recommended, especially because there are much less toxic alternatives, such as diazepam.
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