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Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue.
This type of connective tissue is found mostly in the reticular layer (or deep layer) of the dermis. [3] It is also in the sclera and in the deeper skin layers. Due to high portions of collagenous fibers, dense irregular connective tissue provides strength, making the skin resistant to tearing by stretching forces from different directions.
Certain diseases such as neuroendocrine tumor of the small intestine (also known by the obsolete term carcinoid), which sometimes release large amounts of 5-hydroxytryptamine, commonly known as 5-HT or serotonin into the blood, may produce a characteristic pattern of mostly right-sided cardiac fibrosis which can be identified with echocardiography.
The heart's cardiac skeleton comprises four dense connective tissue rings that encircle the mitral and tricuspid atrioventricular (AV) canals and extend to the origins of the pulmonary trunk and aorta. This provides crucial support and structure to the heart while also serving to electrically isolate the atria from the ventricles. [1]
Cardiac CT (CCT) is a modified form of the traditional chest CT due to the difficulty of imaging the complex, moving heart. [16] This is achieved through the use of thin slices and high-resolution scanning, as well as the addition of electrocardiogram (ECG) gating or triggering to capture a motion-free image.
Valvular heart disease resulting from rheumatic fever is referred to as rheumatic heart disease. Acute rheumatic fever, which frequently manifests with carditis and valvulitis, [ 20 ] is a late sequela of Group A beta-hemolytic streptococcus infection in the throat, often lagging the initial infection by weeks to months. [ 21 ]
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