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  2. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.

  3. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    [4] [5] [6] They are commonly prescribed to treat and prevent blood clots in veins, prevent stroke and embolism in people with non-valvular atrial fibrillation (AF) who have other risk factors, and prevent blood clots after routine knee and hip replacement surgery. [2] [3] [7]

  4. Osteoporosis - Wikipedia

    en.wikipedia.org/wiki/Osteoporosis

    The US National Osteoporosis Foundation recommends pharmacologic treatment for patients with hip or spine fracture thought to be related to osteoporosis, those with BMD 2.5 SD or more below the young normal mean (T-score -2.5 or below), and those with BMD between 1 and 2.5 SD below normal mean whose 10-year risk, using FRAX, for hip fracture is ...

  5. U.S. FDA Approves ELIQUIS® (apixaban) to Reduce the ... - AOL

    www.aol.com/news/2013-01-02-us-fda-approves...

    U.S. FDA Approves ELIQUIS ® (apixaban) to Reduce the Risk of Stroke and Systemic Embolism in Patients with Nonvalvular Atrial Fibrillation ELIQUIS Demonstrated Superior Risk Reductions Versus ...

  6. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...

  7. Vitamin D not recommended for preventing fractures in older ...

    www.aol.com/vitamin-d-not-recommended-preventing...

    The U.S. Preventive Services Task Force released a draft recommendation advising against using vitamin D to prevent falls and fractures in people over 60. Pharmacist Katy Dubinsky weighs in.

  8. Tibial plateau fracture - Wikipedia

    en.wikipedia.org/wiki/Tibial_plateau_fracture

    Tibial plateau fracture; Other names: Fractures of the tibial plateau: A severe tibial plateau fracture with an associated fibular head fracture: Specialty: Orthopedics: Symptoms: Pain, swelling, decreased ability to move the knee [1] Complications: Injury to the artery or nerve, compartment syndrome [1] Types: Type I to Type VI [2] Causes

  9. Woman, 26, slashed in neck and man, 42, wrist cut in NYC ...

    www.aol.com/woman-26-slashed-neck-man-153151215.html

    A suspect is in custody after a knife attack at Grand Central 42 Street subway station in New York injured two with neck and wrist slashes.