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As with all hormonal therapies, GnRH antagonists are commonly associated with hormonal side effects such as hot flushes, headache, nausea and weight gain. [ 18 ] [ 19 ] [ 20 ] When used in fertility treatment they can also be associated with abdominal pain and ovarian hyperstimulation.
Leuprorelin, also known as leuprolide, is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, for early puberty, or as part of transgender hormone therapy. [10] [11] It is given by injection into a muscle or under the skin. [10]
A gonadotropin-releasing hormone antagonist (GnRH antagonist) is a GnRH modulator that blocks the GnRH receptor resulting in an immediate drop in gonadotropin (FSH, LH) secretion. GnRH antagonists are primarily used in IVF treatments to block natural ovulation.
[1] [2] [5] This in turn results in antiestrogenic effects that may be useful in the treatment of estrogen-dependent conditions. [1] [2] [5] As of November 2023, the drug is in phase 2 clinical trials for endometriosis. [1] [2] It is also under preclinical investigation for treatment of breast cancer and endometrial cancer. [5]
Ganirelix is a synthetic peptide that works as an antagonist against gonadotropin-releasing hormone (GnRH) ("Ganirelix acetate injection," 2009). Ganirelix competitively blocks GnRH receptors on the pituitary gonadotroph, quickly resulting in the suppression of gonadotropin secretion. [6]
“Depending on your symptoms and priorities, we may prescribe hormonal medications, such as birth control pills or progesterone, to modify the endometriosis lesions.” But if symptoms persist ...
Endometriosis is associated with elevated levels of the female sex hormone estrogen, as well as estrogen receptor sensitivity. [19] Estrogen exposure worsens the inflammatory symptoms of endometriosis by stimulating an immune response. [20] [21] While there is no cure for endometriosis, several treatments may improve symptoms. [1]
Endometriosis is an estrogen-dependent condition, meaning it relies on estrogen for its growth and progression. Therefore, zinc in high doses might be an endocrine disruptor , upsetting the body ...