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This illustration demonstrates the normal kidney physiology, including the Proximal Convoluted Tubule (PCT), Loop of Henle, and Distal Convoluted Tubule (DCT). It also includes illustrations showing where some types of diuretics act, and what they do. Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney.
The first step in urine formation is the filtration of blood in the kidneys. In a healthy human, the kidney receives between 12 and 30% of cardiac output, but it averages about 20% or about 1.25 L/min. The basic structural and functional unit of the kidney is the nephron.
The filtration fraction is the amount of plasma that is actually filtered through the kidney. This can be defined using the equation. The kidney is a very complex organ and mathematical modelling has been used to better understand kidney function at several scales, including fluid uptake and secretion. [35] [36]
In multilobar kidneys, the pyramids are separated from each other by dipped into the kidney areas of cortical tissue known as the renal columns. [61] Blood enters the kidney through the renal artery, which in the multilobar kidney then branches in the region of the renal pelvis into large interlobar arteries that pass through the renal columns.
The concave part of the bean-shaped kidneys is called the renal hilum, through which the renal artery and nerves enter the kidney. The renal vein, collecting lymphatic vessels and ureter exit the kidney through the renal hilum. [6] [55] The kidneys are located retroperitoneally [6] on the back wall of the body of mammals. [7]
When IDMS-calibrated serum creatinine is used (which is about 6% lower), the above equations should be multiplied by 175/186 or by 0.94086. [34] Since these formulae do not adjust for body size, results are given in units of mL/min per 1.73 m 2, 1.73 m 2 being the estimated body surface area of an adult with a mass of 63 kg and a height of 1.7 m.
"Third spacing" is the abnormal accumulation of fluid into an extracellular and extravascular space. In medicine, the term is often used with regard to loss of fluid into interstitial spaces, such as with burns or edema, but it can also refer to fluid shifts into a body cavity (transcellular space), such as ascites and pleural effusions. With ...
Nephrology (from Ancient Greek nephros 'kidney' and -logy 'the study of') is a specialty for both adult internal medicine and pediatric medicine that concerns the study of the kidneys, specifically normal kidney function (renal physiology) and kidney disease (renal pathophysiology), the preservation of kidney health, and the treatment of kidney disease, from diet and medication to renal ...