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Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation [5] [7] and for the treatment of dry eye syndrome. [ 6 ] [ 8 ] It is a nicotinic acetylcholine receptor partial agonist .
Varenicline more than doubled the chances of quitting compared to placebo, and was also as effective as combining two types of NRT. 2 mg/day of varenicline has been found to lead to the highest abstinence rate (33.2%) of any single therapy, while 1 mg/day leads to an abstinence rate of 25.4%.
Varenicline tartrate: Champix, Chantix 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine [27] Film coated tablet Partial agonist of the nicotinic acetylcholine receptor, subtype α 4 β 2 [28] Treatment of tobacco dependence [28] Galantamine hydrobromide: Reminyl, Nivalin, Razadyne and Razadyn ER
The Recent work has demonstrated a potential role in reducing inflammatory neurotoxicity in stroke, myocardial infarction, sepsis, and Alzheimer's disease. [4] [5] [6]The α7 receptor is highly implicated in the efficacy of Varenicline for smoking cessation therapy significantly more than α4β2 which is responsible for Nicotine's rewarding effects.
This multi-page article lists pharmaceutical drugs alphabetically by name. Many drugs have more than one name and, therefore, the same drug may be listed more than once. ...
The success rate for Chantix appears to be about 44% after three months, far above other products on the market. The one year success rate is about 22%, still far higher than other methods of quitting. The reason for this drop is because Chantix is a tool, not a magic pill, and nicotine is an insidious addiction.
Dianicline is very similar to the already marketed drug varenicline and it is unclear what advantages it will have over the older drug, although it may have an improved side effect profile. It has been through human trials up to Phase II, although results have not yet been reported.
A parasympathomimetic drug, sometimes called a cholinomimetic drug [1] or cholinergic receptor stimulating agent, [2] is a substance that stimulates the parasympathetic nervous system (PSNS).