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AOH1996 was created to target a post-translationally modified isoform of PCNA, termed caPCNA, which is preferentially found in cancer cells. PCNA is crucial in the body for DNA repair, but targeting it is difficult because of its role in healthy cells.
18538 Ensembl ENSG00000132646 ENSMUSG00000027342 UniProt P12004 P17918 RefSeq (mRNA) NM_182649 NM_002592 NM_011045 RefSeq (protein) NP_002583 NP_872590 NP_035175 Location (UCSC) Chr 20: 5.11 – 5.13 Mb Chr 2: 132.09 – 132.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cryo-EM structure of the DNA-bound PolD–PCNA processive complex Proliferating cell nuclear antigen (PCNA) is ...
The 2025 4 Nations Face-Off (French: Confrontation des 4 nations) was an international ice hockey tournament held from February 12 to 20, 2025. The games were played in Montreal at Bell Centre and in Boston at TD Garden.
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The categorisation of the past into discrete, quantified named blocks of time is called periodization. [1] This is a list of such named time periods as defined in various fields of study.
A 19-year-old college student who went missing from Pasadena, Texas, on Feb. 8 has been found slain in Houston.. The Pasadena Police Department is actively investigating the death of Payas Deo ...
George Pickens might catch plenty of footballs, but he's not catching a break with a nagging hamstring injury.. The Steelers receiver suffered the injury in practice ahead of Week 14 and the ...