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Clindamycin may prolong the effects of neuromuscular-blocking drugs, such as succinylcholine and vecuronium. [55] [56] [57] Its similarity to the mechanism of action of macrolides and chloramphenicol means they should not be given simultaneously, as this causes antagonism [26] and possible cross-resistance. [medical citation needed]
Clindamycin alone has been shown to be efficacious in the treatment of acne, [24] toxic shock syndrome [25] and malaria, [26] and to decrease the risk of premature births in women with bacterial vaginosis. [27] Lincosamide antibiotics may also be useful in the treatment of methicillin-resistant S. aureus. [28]
Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a macrolide and was originally developed as an antifungal, but has since been used as an immunosuppressant drug and is being investigated as a potential longevity ...
The incidence of inner ear toxicity varies from 7 to 90%, depending on the types of antibiotics used, susceptibility of the patient to such antibiotics, and the duration of antibiotic administration. [20] Another serious and disabling side effect of aminoglycoside use is vestibular ototoxicity. [19]
John Marshall used to enjoy running but after a serious reaction to antibiotics in 2017 he was left barely able to walk. The 51-year-old from Kirkcaldy says his health changed dramatically after ...
With regard to antibiotics, antivirals, and other agents indicated for treatment of infectious pathological disease, drugs of last resort are commonly withheld from administration until after the trial and failure of more commonly used treatment options to prevent the development of drug resistance.
Ototoxicity is the property of being toxic to the ear (oto-), specifically the cochlea or auditory nerve and sometimes the vestibular system, for example, as a side effect of a drug. The effects of ototoxicity can be reversible and temporary, or irreversible and permanent. It has been recognized since the 19th century. [1]
But in 2024, after four months on Zepbound, I was forced to stop taking it. ... I didn’t have any adverse physical side effects after stopping, but the food noise came back immediately.