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Alpha-gal syndrome (AGS), also known as alpha-gal allergy or mammalian meat allergy (MMA), [1] is a type of acquired allergy characterized by a delayed onset of symptoms (3–8 hours) after ingesting mammalian meat. The condition results from past exposure to certain tick bites and was first reported in 2002.
The symptoms of Alpha-gal syndrome. AGS can cause a range of symptoms: mild ones like a rash or hives, or more severe ones such as difficulty breathing, and even anaphylaxis, says infectious ...
What is alpha-gal syndrome? The lone star tick can cause an allergic reaction known as alpha-gal syndrome. The tick's saliva contains a sugar molecule called galactose-alpha-1,3-galactose (alpha-gal).
The range of symptoms is vast; alpha-gal syndrome can cause hives, heartburn, nausea or vomiting, diarrhea, drops in blood pressure, dizziness, severe stomach pain, and even anaphylaxis.
Name Possible reaction(s) Remarks Balsam of Peru: Redness, swelling, itching, allergic contact dermatitis reactions, stomatitis (inflammation and soreness of the mouth or tongue), cheilitis (inflammation, rash, or painful erosion of the lips, oropharyngeal mucosa, or angles of their mouth), pruritus, hand eczema, generalized or resistant plantar dermatitis, rhinitis, conjunctivitis, and blisters.
When the same tick attaches to the next host (e.g., a human) it transfers the alpha-gal to the tissues of that next host. The immune system of some humans recognises alpha-gal as foreign and so produces antibodies against it. In this case the antibody produced is IgE, which is the type of antibody responsible for most allergic reactions.
Alpha-gal syndrome symptoms. Symptoms can vary from person to person, ranging from mild to severe to life-threatening, the CDC said. In a person with alpha-gal syndrome, symptoms typically appear ...
Alpha gal has also been suggested to play a role in an immunoglobulin E-specific allergic response to some meats. [4] While this allergic response is quite well documented, there is significant discrepancy between laboratory tests and clinical findings, indicating that much research must still be done on the alpha gal mechanism of action and ...
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