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  2. LDL receptor - Wikipedia

    en.wikipedia.org/wiki/LDL_receptor

    The LDLR gene resides on chromosome 19 at the band 19p13.2 and is split into 18 exons. [8] Exon 1 contains a signal sequence that localises the receptor to the endoplasmic reticulum for transport to the cell surface.

  3. Reference ranges for blood tests - Wikipedia

    en.wikipedia.org/wiki/Reference_ranges_for_blood...

    A reference range is usually defined as the set of values 95 percent of the normal population falls within (that is, 95% prediction interval). [2] It is determined by collecting data from vast numbers of laboratory tests.

  4. LRP1 - Wikipedia

    en.wikipedia.org/wiki/LRP1

    Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the ...

  5. Diego antigen system - Wikipedia

    en.wikipedia.org/wiki/Diego_antigen_system

    Anti-Di b was found in 1967, establishing the Diego group as a two-antigen system. In 1993 the Diego pair of antigens was found to result from a single point mutation (nucleotide 2561) on what is now called the SLC4A1 gene on chromosome 17. [1] The Wright a antigen (Wr a), a very low frequency blood type, was also discovered in 1953.

  6. Complementarity-determining region - Wikipedia

    en.wikipedia.org/wiki/Complementarity...

    A single antibody molecule has two antigen receptors and therefore contains twelve CDRs total. There are three CDR loops per variable domain in antibodies. Sixty CDRs can be found on a pentameric IgM molecule, which is composed of five antibodies and has increased avidity as a result of the collective affinity of all antigen-binding sites combined.

  7. Failed negotiations resulted in union members walking out on ...

    www.aol.com/news/failed-negotiations-resulted...

    The union said the tactic is a common anti-union practice, which it is fighting through its unfair labor practice charge on management’s misclassification of members, in an attempt to shrink the ...

  8. Managers are getting less training, and it's hurting companies

    www.aol.com/managers-getting-less-training...

    In general, people have less confidence in their bosses than they did a few years ago. Gallup's data shows that only 1 in 5 employees strongly trust the leadership within their organizations, with ...

  9. Familial hypercholesterolemia - Wikipedia

    en.wikipedia.org/wiki/Familial_hypercholesterolemia

    Homozygotes have LDLR activity of less than 2%, while heterozygotes have defective LDL processing with receptor activity being 2–25%, depending on the nature of the mutation. Over 1000 different mutations are known. [4] There are five major classes of FH due to LDLR mutations: [12] Class I: LDLR is not synthesized at all.

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