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Non-24-hour sleep–wake disorder (non-24, [1] N24SWD, [2] or N24) is one of several chronic circadian rhythm sleep disorders (CRSDs). It is defined as a "chronic steady pattern comprising [...] daily delays in sleep onset and wake times in an individual living in a society". [3]
It consists of going to bed two or more hours later each day for several days until the desired bedtime is reached, and it often must be repeated every few weeks or months to maintain results. Its safety is uncertain, [41] notably because it has led to the development of non-24-hour sleep-wake rhythm disorder, a much more severe disorder. [9]
Non-24-hour sleep–wake disorder (N24SWD): Most common in individuals that are blind and unable to detect light, is characterized by chronic patterns of sleep/wake cycles that are not entrained to the 24 h light–dark environmental cycle. As a result of this, individuals with this disorder will usually experience a gradual yet predictable ...
Chronotherapy has been known to cause non-24-hour sleep–wake disorder in at least three recorded cases, as reported in the New England Journal of Medicine in 1992. Animal studies have suggested that such lengthening could "slow the intrinsic rhythm of the body clock to such an extent that the normal 24-hour day no longer lies within its range ...
Non-24-hour sleep–wake disorder This page was last edited on 12 January 2025, at 18:13 (UTC). Text is available under the Creative Commons Attribution ...
Free-running sleep is a rare sleep pattern whereby the sleep schedule of a person shifts later every day. [1] It occurs as the sleep disorder non-24-hour sleep–wake disorder or artificially as part of experiments used in the study of circadian and other rhythms in biology.
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Tasimelteon, sold under the brand name Hetlioz, is a medication approved by the U.S. Food and Drug Administration (FDA) [3] in January 2014, for the treatment of non-24-hour sleep–wake disorder (also called non-24, N24 and N24HSWD). [4]
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