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Calcium regulation in the human body. [6]The plasma ionized calcium concentration is regulated within narrow limits (1.3–1.5 mmol/L). This is achieved by both the parafollicular cells of the thyroid gland, and the parathyroid glands constantly sensing (i.e. measuring) the concentration of calcium ions in the blood flowing through them.
546729 Ensembl ENSG00000185933 ENSMUSG00000079258 UniProt Q8IU99 D3Z291 RefSeq (mRNA) NM_001001412 NM_001081271 RefSeq (protein) NP_001001412 NP_001074740 Location (UCSC) Chr 10: 103.45 – 103.46 Mb Chr 19: 47.13 – 47.13 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Calcium homeostasis modulator 1 (CALHM1) is a pore-forming subunit of a voltage-gated ion channel and a voltage ...
Calcium-binding proteins have specific domains that bind to calcium and are known to be heterogeneous. One of the functions of calcium binding proteins is to regulate the amount of free (unbound) Ca 2+ in the cytosol of the cell. [1] The cellular regulation of calcium is known as calcium homeostasis.
The US Institute of Medicine (IOM) established Recommended Dietary Allowances (RDAs) for calcium in 1997 and updated those values in 2011. [6] See table. The European Food Safety Authority (EFSA) uses the term Population Reference Intake (PRIs) instead of RDAs and sets slightly different numbers: ages 4–10 800 mg, ages 11–17 1150 mg, ages 18–24 1000 mg, and >25 years 950 mg. [10]
The protein encoded by this gene is a highly conserved, calcium-binding protein, ... [10] [11] It may have an important role in calcium homeostasis.
The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ions. It is primarily expressed in the parathyroid gland, the renal tubules of the kidney and the brain. [5] [6] In the parathyroid gland, it controls calcium homeostasis by regulating the release of parathyroid hormone (PTH ...
It acts to reduce blood calcium (Ca 2+), opposing the effects of parathyroid hormone (PTH). [7] Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. [8] It belongs to the calcitonin-like protein family.
SLC24A6 belongs to a family of Potassium-dependent sodium-calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion. [6]