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An example is sodium thiosulfate, which the US FDA approved in 2022 to minimise the risk of ototoxicity and hearing loss in newborn, child, and adolescent cancer patients receiving cisplatin. [ 29 ] [ 30 ] [ 31 ] Other agents being investigated for their potential to reduce ototoxicity include D-methionine and L-N-acetylcysteine . [ 3 ]
Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g., small cell lung cancer, squamous cell carcinoma of the head and neck and ovarian cancer), lymphomas, bladder cancer, cervical cancer, [9] and germ cell tumors.
At high doses, quinine, aspirin and other salicylates may also cause high-pitch tinnitus and hearing loss in both ears, typically reversible upon discontinuation of the drug. [20] Erectile dysfunction medications may have the potential to cause hearing loss. [36] However the link between erectile dysfunction medications and hearing loss remains ...
In September 2022, the U.S. Food and Drug Administration (FDA) approved sodium thiosulfate under the brand name Pedmark to lessen the risk of ototoxicity and hearing loss in infant, child, and adolescent cancer patients receiving the chemotherapy medication cisplatin.
Hearing loss affects one in three people ages 65 to 74, according to the National Institutes of Health. And while hearing aids can greatly improve quality of life, they're often expensive. If you ...
[6] [7] Specific side effects of platinum compounds include hearing loss, tinnitus, and dysesthesia. These symptoms generally begin with the or third cycle of treatment and can last long after treatment completion. Indeed, the “coasting” phenomenon mentioned in the Symptoms section is a direct effect of platinum agents. Of the platinum ...
"The loss of a staff person is difficult, but to lose a family member on Christmas Day at the hands of someone in our custody is a tragedy beyond comprehension," ODRC Director Annette Chambers ...
Hearing loss has multiple causes, including ageing, genetics, perinatal problems and acquired causes like noise and disease. For some kinds of hearing loss the cause may be classified as of unknown cause. [citation needed] There is a progressive loss of ability to hear high frequencies with aging known as presbycusis. For men, this can start as ...