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The initial case in human outbreaks of Nipah virus has always been zoonotic [8] from exposure to contaminated secretions or tissues of infected bats or pigs. Subsequent human-to-human transmission of Nipah virus occurs via close contact with NiV-infected persons or exposure to NiV-infected body fluids (e.g., blood, urine, nasal secretions). [1]
The Nipah virus structural model, constructed at an atomic resolution, depicts a particle with a diameter of 90 nm, adorned with spikes. This model affords a glimpse into the virus's interior. The Nipah virus is known for its high mortality rate and is viewed as a potential candidate for the next pandemic.
Nipah virus (NiV) replication cycle As all mononegaviral genomes, Hendra virus and Nipah virus genomes are non-segmented, single-stranded negative-sense RNA. Both genomes are 18.2 kb in length and contain six genes corresponding to six structural proteins.
While this process is highly efficient in HeV and NiV leading to a broad tropism and effective infection of the virus within the host GhV exhibits a less than effective entry process. While HeV and NiV have strong fusion activity with a variety of host cells, GhV is restricted to a limited host range and only replicates in certain bat cells.
A deadly virus called Nipah carried by bats has already caused human outbreaks across South and South East Asia and has "serious epidemic potential", global health and infectious disease ...
The virus is often transmitted by bats. For premium support please call: 800-290-4726 more ways to reach us
Mononegavirales is an order of negative-strand RNA viruses which have nonsegmented genomes. Some members that cause human disease in this order include Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus.
The state is battling its fourth outbreak since 2018 of a virus for which there is no vaccine, and which spreads through contact with the body fluids of infected bats, pigs or people, killing up ...