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Boronic acids are known to bind to active site serines and are part of inhibitors for porcine pancreatic lipase, [2] subtilisin [3] and the protease Kex2. [4] Furthermore, boronic acid derivatives constitute a class of inhibitors for human acyl-protein thioesterase 1 and 2, which are cancer drug targets within the Ras cycle. [5]
Meanwhile, the azirine intermediate can react with nucleophiles, especially carboxylic acids. Given the photoreactions, isoxazole group is developed as a native photo-cross-linker for photoaffinity labeling and chemoproteomic studies.
Formic acid (HCO 2 H) 3.75 Chloroformic acid (ClCO 2 H) 0.27 [5] Acetic acid (CH 3 CO 2 H) 4.76 Glycine (NH 2 CH 2 CO 2 H) 2.34 Fluoroacetic acid (FCH 2 CO 2 H) 2.586 Difluoroacetic acid (F 2 CHCO 2 H) 1.33 Trifluoroacetic acid (CF 3 CO 2 H) 0.23 Chloroacetic acid (ClCH 2 CO 2 H) 2.86 Dichloroacetic acid (Cl 2 CHCO 2 H) 1.29 Trichloroacetic ...
The reaction can also be carried out at the laboratory scale with diphosgene or triphosgene and an aqueous dimethylamine solution in the two-phase system of benzene–xylene and water in a stirred reactor with sodium hydroxide as an acid scavenger. However, considerably lower yields (56%) are achieved due to the hydrolysis sensitivity of DMCC.
Phenylboronic acid or benzeneboronic acid, abbreviated as PhB(OH) 2 where Ph is the phenyl group C 6 H 5 - and B(OH) 2 is a boronic acid containing a phenyl substituent and two hydroxyl groups attached to boron. Phenylboronic acid is a white powder and is commonly used in organic synthesis.
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Carbamic acid is a planar molecule. [3]The H 2 N− group of carbamic acid, unlike that of most amines, cannot be protonated to an ammonium group H 3 N + −.The zwitterionic form H 3 N + −COO − is very unstable and promptly decomposes into ammonia and carbon dioxide, [6] yet there is a report of its detection in ices irradiated with high-energy protons.
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