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As a result, the minimum infective dose is exactly equal to one bacterial cell, deviating from the traditional notion of the MID. Proportionality has a second consequence: when the dose is divided by ten, the probability of observing the effect is also divided by ten. Additionally, it is a relationship without threshold.
The TCID 50 (50% tissue culture infectious dose) assay is the measure of infectious virus titer. This endpoint dilution assay quantifies the amount of virus required to kill 50% of infected hosts or to produce a cytopathic effect in 50% of inoculated tissue culture cells. This assay may be more common in clinical research applications where the ...
Virulence is a pathogen's or microorganism's ability to cause damage to a host. In most cases, especially in animal systems, virulence refers to the degree of damage caused by a microbe to its host. [1] The pathogenicity of an organism—its ability to cause disease—is determined by its virulence factors.
The infectious dose of norovirus required to produce infection in humans is ... The relative ability of viruses to cause disease is described in terms of virulence.
In epidemiology, infectivity is the ability of a pathogen to establish an infection. More specifically, infectivity is the extent to which the pathogen can enter, survive, and multiply in a host. It is measured by the ratio of the number of people who become infected to the total number exposed to the pathogen. [1]
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. [1] An infectious disease , also known as a transmissible disease or communicable disease , is an illness resulting from an infection.
A viral infection does not always cause disease. A viral infection simply involves viral replication in the host, but disease is the damage caused by viral multiplication. [5] An individual who has a viral infection but does not display disease symptoms is known as a carrier. [17] Mechanisms by which viruses cause damage and disease to host cells
Virulence factors are the weapons possessed by pathogens to cause damage to the host, hence they are molecules or bacterial cell structures involved in the various stages of pathogenesis such as adhesion, invasion and colonization and also in the ability to escape host defenses and to injury the host tissues by producing toxic molecules ...