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Ketogenesis pathway. The three ketone bodies (acetoacetate, acetone, and beta-hydroxy-butyrate) are marked within orange boxes. Ketogenesis is the biochemical process through which organisms produce ketone bodies by breaking down fatty acids and ketogenic amino acids.
Ketone bodies are water-soluble molecules or compounds that contain the ketone groups produced from fatty acids by the liver (ketogenesis). [1] [2] Ketone bodies are readily transported into tissues outside the liver, where they are converted into acetyl-CoA (acetyl-Coenzyme A) – which then enters the citric acid cycle (Krebs cycle) and is oxidized for energy.
Exogenous ketones are a class of ketone bodies that are ingested using nutritional supplements or foods. This class of ketone bodies refers to the three water-soluble ketones ( acetoacetate , β-hydroxybutyrate [β-HB] , and acetone ). [ 1 ]
Ketones contain a carbonyl group −C(=O)− (a carbon-oxygen double bond C=O). The simplest ketone is acetone (where R and R' is methyl), with the formula (CH 3) 2 CO. Many ketones are of great importance in biology and industry. Examples include many sugars , many steroids (e.g., testosterone), and the solvent acetone. [1]
[1] [2] The simplest ketose is dihydroxyacetone ((CH 2 OH) 2 C=O), which has only three carbon atoms. It is the only ketose with no optical activity . All monosaccharide ketoses are reducing sugars , because they can tautomerize into aldoses via an enediol intermediate, and the resulting aldehyde group can be oxidised , for example in the ...
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Proteins are large molecules made up of amino acids that perform essential functions in our cells. They are vital for immune response, muscle activity, and cognitive processes.